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TMA® TECHNOLOGY
MOTION & HEAT: THE ULTIMATE COMBINATION
TMA® TECHNOLOGY

ABOUT TMA®
THERMO-MECHANICAL
ACTION TECHNOLOGY

TMA® is a technology, specially developed by Novoxel®, that’s forward in thinking and in its action. It uniquely combines motion and heat with the forward movement of a medical-grade titanium tip. This proprietary non-laser fractional technology transfers thermal energy to skin very quickly and safely: energy is emitted through a matrix of tiny pyramid-shaped pins made of biocompatible materials covering a treatment area of 1cm². The pins are heated to a temperature of 400°C and are self-sterilized.

ABOUT TMA®THERMO-MECHANICAL ACTION TECHNOLOGY

THE THERMAL EFFECT

THE THERMAL EFFECT

During treatment, the pins are introduced to the surface of the skin at a precisely-controlled speed and create brief contact with the skin lasting only a few milliseconds. This enables the thermal energy stored in the pins to be transferred to the skin. The thermal transfer results in an array of tiny non-ablative coagulation sites. Because the tiny tip pyramids hold a limited amount of energy, burns and tissue charring are prevented.

WHY IS THE PAIN RELATIVELY LOW?

The reason why pain is relatively low during treatment with Tixel® compared to the ablative CO₂ laser is primarily due to the transfer of a relatively lower amount of energy to the skin by Tixel®. This is made possible by utilization of a more efficient energy transfer method (conduction vs. radiation) and the longer pulse duration (e.g. 10ms vs. 1ms) of Tixel as compared to the CO₂ laser. 

ENHANCED SKIN PERMEABILITY

Research shows that TMA™ creates superficial channels in the stratum corneum, allowing enhanced permeability to topically applied hydrophilic substances, that are applied after treatment. Tixel®’s intended use does not currently include tissue permeability enhancement.

ENHANCED SKIN PERMEABILITY

Treatment Results

Harryono Judodihardjo, MD, England
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Xavier Martens, MD, Belgium
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Li Lin Liu, MD, Taiwan
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Uichi Sai, MD, Tokyo, Japan
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Uichi Sai, MD, Tokyo, Japan
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Li Lin Liu, MD, Taiwan
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Lehavit Akerman, MD, Israel Combination treatment with skin booster
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Lehavit Akerman, MD, Israel Combination Treatment
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Lehavit Akerman, MD, Israel Combination Treatment with skin booster and Hifu
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Melasma A. Margaritescu, MD, Romania Combination Treatment
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Ofir Artzi, MD, Israel
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Susan Khouw, MD, Germany
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Ofir Artzi, MD, Israel
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Susan Khouw, MD
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Dawn Richardson, RN, UK.
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CLINICAL EVIDENCE

Safety and Effectiveness of a Thermo-Mechanical Fractional System at Low Settings for the Treatment of Photodamage
2025 February 10

Safety and Effectiveness of a Thermo-Mechanical Fractional System at L..

Eric F Bernstein, Maggie Wang, Jennifer Wang, J Lee Pannell
Read Article
Percutaneous delivery of liquid tetracycline using a thermal resurfacing drug delivery system for the treatment of festoons
2024 April 11

Percutaneous delivery of liquid tetracycline using a thermal resurfaci..

Margarita Safir, Inbar Waizer, Ari Safir, Morris E Hartstein, Ofir Artzi
Read Article
Thermomechanical Fractional Injury Therapy Delivers Satisfactory Results, Less Pain With Surface Anesthesia
2024 April 30

Thermomechanical Fractional Injury Therapy Delivers Satisfactory Resul..

Richard Mark Kirkner
Read Article
Frontal Fibrosing Alopecia-Related Facial Papules Successfully Treated With a Thermomechanical Fractional Injury Device
2024 April 18

Frontal Fibrosing Alopecia-Related Facial Papules Successfully Treated..

Taciana Dal'Forno, Martina Souilljee Birck
Read Article
Effectiveness and safety of a thermo-mechanical action device versus thermal pulsation device in the treatment of meibomian gland dysfunction
2024 April 18

Effectiveness and safety of a thermo-mechanical action device versus t..

E Sadri, A Verachtert, G D Parkhurst, J Echegoyen, I Klein, Y G Agmon, G J Berdy
Read Article
Safety and Efficacy of a Thermomechanical Fractional Injury Device for Periorbital Rhytides
2023 February 22

Safety and Efficacy of a Thermomechanical Fractional Injury Device for..

Jordan V Wang, Shirin Bajaj, David Orbuch, Moshe Lapidoth, Ifat Klein, Yael Agmon Gerste
Read Article
Prospective Evaluation of the Safety and Efficacy of Thermomechanical Fractional Injury for Perioral Rhytides
2023 March 16

Prospective Evaluation of the Safety and Efficacy of Thermomechanical ..

Jordan V Wang, Shirin Bajaj, Alexa Steuer, David Orbuch, Roy G Geronemus
Read Article
Comprehensive Review of Thermomechanical Fractional Injury Device: Applications in Medical and Cosmetic Dermatology
2024 February 17

Comprehensive Review of Thermomechanical Fractional Injury Device: App..

Blanca Estupiñan, Adam Souchik, Alexandra Kiszluk, Shraddha Desai
Read Article
Impact of thermo-mechanical skin treatment on refraction and keratometry in patients with dry eye disease and the implications for cataract surgery
2024 April 08

Impact of thermo-mechanical skin treatment on refraction and keratomet..

Marta Blanco-Vázquez, Raquel Gil-Cazorla, Ankur Barua, Mukesh Taneja, Ludger Hanneken, Sunil Shah
Read Article
The effect of non-ablative thermomechanical skin treatment (Tixel®) on dry eye disease: A prospective two centre open-label trial
2023 January 10

The effect of non-ablative thermomechanical skin treatment (Tixel®) o..

Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A Naroo
Read Article
The effect of thermo-mechanical device (Tixel) treatment on evaporative dry eye disease - A pilot prospective clinical trial
2022 July 18

The effect of thermo-mechanical device (Tixel) treatment on evaporativ..

M Safir, I Hecht, A Ahimor, S Zmujack-Yehiam, R Stein, E Bakshi, A Einan-Lifshitz 2, M E Hartstein
Read Article
Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery
2022 January 01

Evaluation of Device-Based Cutaneous Channels Using Optical Coherence ..

Jordan V Wang, Joseph N Mehrabi, Christopher B Zachary, Roy G Geronemus
Read Article
Efficacy and safety of a thermal fractional skin rejuvenation system (Tixel) for the treatment of facial and/or scalp actinic keratoses
2022 April 12

Efficacy and safety of a thermal fractional skin rejuvenation system (..

Shabtai, Sloutsky, Lapidoth, Mimouni, Chorny, Snast, Leshem, Friedland, Hodak, Klein, Agmon, Levi
Read Article
Efficacy and safety of thermomechanical fractional injury‐assisted corticosteroid delivery versus intralesional corticosteroid injection for the treatment of hypertrophic scars: A randomized split‐scar trial
2021 December 16

Efficacy and safety of thermomechanical fractional injury‐assisted c..

W Manuskiatti, C Yan, O Artzi, M K R Gervasio, R Wanitphakdeedecha
Read Article
Retrospective study on the safety and tolerability of clinical treatments with a novel Thermomechanical Ablation device on 150 patients
2021 June 06

Retrospective study on the safety and tolerability of clinical treatme..

Harryono Judodihardjo, Sajjad Rajpar
Read Article
Treatment of periorbital wrinkles using thermo‐mechanical fractional injury therapy versus fractional non‐ablative 1565 nm laser: A comparative prospective, randomized, double‐arm, controlled study
2021 November 17

Treatment of periorbital wrinkles using thermo‐mechanical fractional..

Fares Salameh, Danny Daniely, Arielle Kauvar, Rafael L Carasso, Joseph N Mehrabi, Ofir Artzi
Read Article
Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review
2020 March 02

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvena..

Danny Daniely, Harryono Judodihardjo, Sajjad F Rajpar, Joseph N Mehrabi, Ofir Artzi
Read Article
Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epidermis‐ Protoporphyrin IX Fluorescence: Comparison of 5‐Aminolevulinic Acid in Cream and Gel Vehicles
2020 October 01

Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epi..

C Foged, M Haedersdal, L Bik, C Dierickx, P A Phillipsen, K Togsverd-Bo
Read Article
Wound Healing Process After Thermomechanical Skin Ablation
2020 January 13

Wound Healing Process After Thermomechanical Skin Ablation

G Kokolakis, L von Grawert, M Ulrich, J Lademann, T Zuberbier, M Hofmann
Read Article
Enhanced percutaneous delivery of Beta-blockers using thermal resurfacing drug delivery system for topical treatment of infantile hemangiomas.
2020 July 10

Enhanced percutaneous delivery of Beta-blockers using thermal resurfac..

Jacob Mashiah, Efrat Bar-Ilan, Amir Koren, Or Friedman, Eyal Zur, Ofir Artzi
Read Article
Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients
2020 April 09

Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatm..

Y Hilerowicz, O Friedman, E Zur, R Ziv, A Koren, F Salameh, J N Mehrabi, O Artzi
Read Article
An enhanced transcutaneous delivery of botulinum toxin for the treatment of Hailey-Hailey disease
2019 December 27

An enhanced transcutaneous delivery of botulinum toxin for the treatme..

Efrat Bar-Ilan, Amir Koren, Wasim Shehadeh, Jacob Mashiah, Eli Sprecher, Ofir Artzi
Read Article
A New Method for Percutaneous Drug Delivery by Thermo-Mechanical Fractional Injury
2019 June 28

A New Method for Percutaneous Drug Delivery by Thermo-Mechanical Fract..

Ronen Shavit, Christine Dierickx
Read Article
A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery
2020 January 20

A new approach in the treatment of pediatric hypertrophic burn scars: ..

Ofir Artzi, Amir Koren, Roni Niv, Joseph N Mehrabi, Jacob Mashiah, Or Friedman
Read Article
The Scar Bane, Without the Pain: A New Approach in the Treatment of Elevated Scars: Thermomechanical Delivery of Topical Triamcinolone Acetonide and 5-Fluorouracil
2019 April 30

The Scar Bane, Without the Pain: A New Approach in the Treatment of El..

Ofir Artzi, Amir Koren, Roni Niv, Joseph N. Mehrabi, Or Friedman
Read Article
Treatment of port wine stain with Tixel-induced rapamycin delivery following pulsed dye laser application
2019 December 04

Treatment of port wine stain with Tixel-induced rapamycin delivery fol..

Ofir Artzi, Jos N. Mehrabi, Lee Heyman, Or Friedman, Jacob Mashiah
Read Article
The toxic edge-A novel treatment for refractory erythema and flushing of rosacea
2018 October 12

The toxic edge-A novel treatment for refractory erythema and flushing ..

Or Friedman, Amir Koren, Roni Niv, Joseph N. Mehrabi, Ofir Artzi
Read Article
A novel thermo-mechanical system enhanced transdermal delivery of hydrophilic active agents by fractional ablation
2019 June 29

A novel thermo-mechanical system enhanced transdermal delivery of hydr..

Amnon C. Sintov, Maja A. Hofmann
Read Article
Fractional treatment of aging skin with Tixel, a clinical and histological evaluation
2016 January 20

Fractional treatment of aging skin with Tixel, a clinical and histolog..

Monica Elman, Nathalie Fournier, Gilbert Barnéon, Eric F. Bernstein, Gary Lask
Read Article
Fractional vaporization of tissue with an oscillatory array of high temperature rods: part I: ex vivo study
2012 October 14

Fractional vaporization of tissue with an oscillatory array of high te..

Gary Lask , Monica Elman, Nathalie Fournier, Michael Slatkine
Read Article
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