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TMA™ TECHNOLOGY
MOTION & HEAT: THE ULTIMATE COMBINATION
TMA™ TECHNOLOGY

ABOUT TMA™
THERMO-MECHANICAL
ACTION TECHNOLOGY

TMA™ is a technology, specially developed by Novoxel, that’s forward in thinking and in its action. It uniquely combines motion and heat with the forward movement of a medical-grade titanium tip. This proprietary non-laser fractional technology transfers thermal energy to skin very quickly and safely: energy is emitted through a matrix of tiny pyramid-shaped pins made of biocompatible materials covering a treatment area of 1cm². The pins are heated to a temperature of 400°C and are self-sterilized.

ABOUT TMA™THERMO-MECHANICAL ACTION TECHNOLOGY

THE THERMAL EFFECT

THE THERMAL EFFECT

During treatment, the pins are introduced to the surface of the skin at a precisely-controlled speed and create brief contact with the skin lasting only a few milliseconds. This enables the thermal energy stored in the pins to be transferred to the skin. The thermal transfer results in an array of tiny non-ablative coagulation sites. Because the tiny tip pyramids hold a limited amount of energy, burns and tissue charring are prevented.

WHY IS THE PAIN RELATIVELY LOW?

The reason why pain is relatively low during treatment with Tixel® compared to the ablative CO₂ laser is primarily due to the transfer of a relatively lower amount of energy to the skin by Tixel®. This is made possible by utilization of a more efficient energy transfer method (conduction vs. radiation) and the longer pulse duration (e.g. 10ms vs. 1ms) of Tixel as compared to the CO₂ laser. The pain nociceptors in skin are located in the epidermis and dermis. These pain receptors are sensitive to the rate at which the temperature changes over time. For example, a CO₂ laser generates heat quickly: CO₂ laser heating to 400°C takes about 200ns whereas the Tixel® heating effect is slower by at least 1 magnitude of order resulting in milder pain.

ENHANCED SKIN PERMEABILITY

Research shows that TMA™ creates superficial channels in the stratum corneum, allowing enhanced permeability to topically applied hydrophilic substances, that are applied after treatment. Tixel®’s intended use does not currently include tissue permeability enhancement.

ENHANCED SKIN PERMEABILITY

Treatment Results

Peri Orbital Wrinkles Harryono Judodihardjo, MD, England
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Peri Orbital Wrinkles Xavier Martens, MD, Belgium
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Eye Lids Lifting / Brow Symmetry Li Lin Liu, MD, Taiwan
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Acne Uichi Sai, MD, Tokyo, Japan
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Acne Uichi Sai, MD, Tokyo, Japan
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Stretch Marks Li Lin Liu, MD, Taiwan
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Neck Lehavit Akerman, MD, Israel Combination treatment
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Décolleté Lehavit Akerman, MD, Israel Combination Treatment
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Neck Lehavit Akerman, MD, Israel Combination Treatment
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Melasma A. Margaritescu, MD, Romania Combination Treatment
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Rosacea Ofir Artzi, MD, Israel Combination Treatment
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Melasma Susan Khouw, MD, Germany
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Acne Ofir Artzi, MD, Israel Combination Treatment
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Acne Scars Susan Khouw, MD, Germany
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CLINICAL EVIDENCE

A New Method for Percutaneous Drug Delivery by Thermo-Mechanical Fractional Injury
2019 June 28

A New Method for Percutaneous Drug Delivery by Thermo-Mechanical Fract..

Ronen Shavit, MSc and Christine Dierickx, MD
Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epidermis‐ Protoporphyrin IX Fluorescence:
Comparison of 5‐Aminolevulinic Acid in Cream and Gel Vehicles
2020 October 01

Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epi..

Camilla Foged, Merete Haedersdal, Liora Bik, Christine Dierickx, Peter Phillipsen, Katrine Togsverd
A Novel Thermo-mechanical System Enhanced Transdermal Delivery of Hydrophilic Active Agents by Fractional Ablation
2019 June 29

A Novel Thermo-mechanical System Enhanced Transdermal Delivery of Hydr..

Amnon C. Sintov, Maja A. Hofmann
Thermo-mechanical ablation assisted photodynamic therapy for the treatment of acne vulgaris. A retrospective chart review of 30 patients.
2020 April 09

Thermo-mechanical ablation assisted photodynamic therapy for the treat..

Y. Hilerowicz, O. Friedman, E. Zur, R. Ziv, A. Koren, F. Salameh, Joseph N. Mehrabi, O. Artzi
Wound Healing Process After Thermomechanical Skin  Ablation.
2019 June 13

Wound Healing Process After Thermomechanical Skin Ablation.

Georgios Kokolakis, Leonie von Grawert, Martina Ulrich, Juergen Lademann, Torsten Zuberbier, and M
The Toxic Edge - A Novel Treatment for Refractory Erythema and Flushing of Rosacea.
2018 October 12

The Toxic Edge - A Novel Treatment for Refractory Erythema and Flushin..

Or Friedman, MD, Amir Koren, MD, Roni Niv, MD, Joseph N. Mehrabi, BSc and Ofir Artzi, MD
The Scar Bane Without the Pain: A New Approach in the Treatment of Elevated Scars: Thermomechanical Delivery of Topical Triamcinolone Acetonide and 5-Fluorouracil  .
2019 June 09

The Scar Bane Without the Pain: A New Approach in the Treatment of Ele..

Ofir Artzi, Amir Koren, Roni Niv, Joseph N. Mehrabi, Or Friedman
A new approach in the treatment of pediatric hypertrophic burn scars: Tixel‐associated topical triamcinolone acetonide and 5‐fluorouracil delivery.
2020 January 20

A new approach in the treatment of pediatric hypertrophic burn scars: ..

Ofir Artzi MD, Amir Koren MD, Roni Niv MD, Joseph N. Mehrabi, Jacob Mashiah MD, Or Friedman MD
Enhanced percutaneous delivery of Beta-blockers using thermal resurfacing drug delivery system for topical treatment of infantile hemangiomas.
2020 July 10

Enhanced percutaneous delivery of Beta-blockers using thermal resurfac..

Jacob Mashiah, MD, Efrat Bar-Ilan, MD, Amir Koren, MD, Or Friedman, MD, Eyal Zur, RPh, Ofir Artzi, M
An Enhanced Transcutenous Delivery of Botulinum Toxin for the Treatment of Hailey-Hailey Disease.
2019 December 27

An Enhanced Transcutenous Delivery of Botulinum Toxin for the Treatmen..

Bar Ilan E, Koren A. Shehadeh W., Mashiah J., Sprecher E., Artzi O.
Treatment of Port Wine Stain with Tixel Induced Rapamycin Delivery Followed by Pulse Dye Laser Application.
2019 December 04

Treatment of Port Wine Stain with Tixel Induced Rapamycin Delivery Fol..

Ofir Artzi, Jos N. Mehrabi, Lee Heyman, Or Friedman, Jacob Mashiah.
Fractional Treatment of Aging Skin with Tixel, a Clinical and Histological Evaluation.
2016 January 20

Fractional Treatment of Aging Skin with Tixel, a Clinical and Histolog..

Monica Elman, Nathalie Fournier, Gilbert Barnיon, Eric F. Bernstein and Gary Lask.
Fractional vaporization of tissue with an oscillatory array of high temperature rods – Part I: Ex vivo study
2012 October 14

Fractional vaporization of tissue with an oscillatory array of high te..

GARY LASK MD, MONICA ELMAN MD , NATHALIE FOURNIER, MD & MICHAEL SLATKINE, PhD
A Prospective Study of the Safety and Efficacy of a Thermo-Mechanical Fractional Ablative
Device for Periorbital Rejuvenation in Asians
2020 February 17

A Prospective Study of the Safety and Efficacy of a Thermo-Mechanical ..

Kwankamol Woottisheattapaiboon, M.D., Woraphong Manuskiatti, M.D., Nudpanuda Tevechodperathum, M.D.
The neck doesn't lie - Tixel® the safe and low-risk treatment option for the treatment of wrinkles in the neck area: Case Report
2018 November 01

The neck doesn't lie - Tixel® the safe and low-risk treatment option ..

Dr. med. Arna Shab, Dr. med. Catharina Shab
Case Study: Treating Severe Photoageing
2017 April 14

Case Study: Treating Severe Photoageing

Dr. Harryono Judodihardjo
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TIXEL WEBINARS

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TIXEL WEBINARS

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